The cooperation between these lymphocytes T CD4 activated by gluten and a soluble factor produced in excess in the patient’s bowel, IL-15, leads to the activation of natural killer cells (CD8), capable of destroying the intestinal epithelium.
These two proteins help present gluten peptides to immune system cells and more particularly to lymphocytes T CD4+. However, this reaction is only observed in people who are genetically susceptible and are carriers of the HLA-DQ2 and HLA-DQ8 molecules. “Proteins in gluten are partially digested by the bowel in the form of peptides, which can penetrate the intestinal wall and in people with celiac disease, activate an immune response,” explains Nadine Cerf-Bensussan. It forms this viscoelastic mass that we get by mixing flour with water and which is used to make bread, pasta and cakes. Gluten corresponds to the insoluble fraction of wheat, barley, rye and spelt flours in water. Celiac disease: an autoimmune diseaseĬeliac disease is caused by an inappropriate response of the immune system to gluten proteins. These problems can be accompanied by osteoporosis, rheumatism, dermatitis herpetiformis, neurological manifestations, infertility, but also autoimmune diseases type I diabetes and thyroiditis. These folds which cover the bowel increase the surface area for absorbing nutrients their disappearance causes most of the symptoms of celiac disease, namely chronic diarrhea, recurrent abdominal pains, bloating, weight loss, anemia sometimes with extraintestinal manifestations. It is related to the destruction of the intestinal mucosa by the immune system, reducing the digestive functions of the bowel and explaining the symptoms of the disease. Today, the disease mechanism is well understood. The diagnosis is relatively simple and consists of a blood analysis to detect the levels of anti-tissue transglutaminase antibodies followed by confirmation with an intestinal endoscopy to show typical intestinal damage and villous atrophy, which does not stop celiac disease from being largely underdiagnosed. However, there are geographic variations depending on genetic factors and gluten consumption. “Like for other inflammatory and chronic diseases and based on studies conducted worldwide, the incidence has probably been increased between 2 to 4 times over the last 50 years” points out Nadine Cerf-Bensussan. In France, 0.5% to 1% of the population would be affected, which is 300,000 to 600,000 people. It is estimated that 1% of the Caucasian population is affected by celiac disease, or gluten intolerance. Make a donation, a legacy or pass on life insuranceĬeliac disease: a poorly diagnosed disease.Corporate Sponsorships and Partnerships.
EXCES DE PROTEINES EFFETS SECONDAIRES HOW TO
:max_bytes(150000):strip_icc()/benefits-of-glutathione-89457_final1-9e6784811b7b4773b30871c05abfe323.png "exces de proteines effets secondaires")
0 kommentar(er)
